细胞内丝裂原活化蛋白激酶信号通路与脑缺血后神经元凋亡

摘要

Cerebralischemiacaninducecelnecrosisincoreoftheinfarction,andapoptosisinthe ischemic penumbra. The mitogen-activated protein kinases (MAPKs) signaling pathw ays are activated after cerebral ischemia, causing programmed cel death, including apoptosis. This article review s the relationship betw een the MAPKs signaling family and neuronal apoptosis after cerebral ischemia.%脑缺血可导致梗死核心区细胞坏死和缺血半暗带细胞凋亡。脑缺血后，丝裂原活化蛋白激酶（mitogen－activated protein kinases， MAPKs）信号通路被激活，引起程序性细胞死亡，包括细胞凋亡。文章就M APKs信号家族与脑缺血后神经元凋亡的关系进行了综述。