急性冠脉综合征血清CC趋化因子19、21和髓过氧化物酶的改变

摘要

目的:探讨血清CC趋化因子19(CCL19)、21(CCL21)和髓过氧化物酶(MPO)水平与急性冠脉综合征的关系.方法:174例冠心病患者分为稳定型心绞痛组(109例)和急性冠脉综合征组(65例),采用ELISA法测定两组血清CCL19、CCL21和MPO水平.结果:急性冠脉综合征组CCL19、CCL21和MPO水平明显高于稳定型心绞痛组;CCL19和CCL21与MPO显著相关.多元Logistic回归分析表明,CCL19、CCL21和MPO是发生急性冠脉综合征的独立危险因素.结论:CCL19、CCL21和MPO可能参与斑块不稳定和急性冠脉综合征的发生.%Objective: To investigate the changes of serum CC-chemokine(CCL)19, CCL21 and myeloperoxidase (MPO) in patients with acute coronary syndrome. Methods:Serum levels of CCL19,CCL21 and MPO were measured by ELISA in 109 patients with stable angina and 65 with acute coronary syndrome (ACS). Results: Serum levels of CCL19, CCL21 and MPO were significantly elevated in patients with ACS than in those with stable angina. CCL19 and CCL21 correlated with MPO. In multivariable regression analysis, CCL19, CCL21. and MPO were independently associated with ACS.Conclusion:Increased serum levels of CCL19, CCL21 and MPO were associated with unstable plaque formation and development of ACS.