目的：应用多焦视网膜电图( multifocal electroretinogram, mf-ERG)测定糖尿病视网膜病变( diabetic retinopathy, DR)患者视网膜电活动,评价不同分期DR患者的视功能损害的严重程度。 方法：选取50~70岁的老年人,除外其他疾病,30例30眼作为正常组；已确诊为2型糖尿病的患者99例99眼做为试验组。分别在标准状态下行mf-ERG检查,对其结果进行统计学分析。 结果：对于DR早期及背景期的患者,mf-ERG的P1波随着病情的加重,其反应密度逐渐下降,在非增殖期就明显减低,而在背景期Ⅲ期时,下降更为明显,说明在黄斑区,视网膜尚未有视觉或形态的改变前,电活动已经减弱,随病情发展,电活动的下降更为明显。 结论：mf-ERG可以评价 DR 的严重程度,尤其适合 DR的早期及背景期。%AlM: To measure the retinal electrical activities in patients with diabetic retinopathy ( DR ) by applying multifocal electroretinogram ( mf-ERG) and evaluate the degree of visual damage at different stages of DR METHODS:Thirty cases ( 30 eyes ) aged 50 ~70 years old, excluding other diseases, were as normal group, and 99 cases ( 99 eyes ) diagnosed with type 2 diabetes were as experiment group. The cases received mf-ERG examination in the standard state, respectively. The results were statistically analyzed RESULTS: For DR patients with early and background stage, the reaction density of mf - ERG P1 wave decreased as the disease worsened, significantly reduced in non - proliferating stage and decreased more significantly in the background of the stage Ⅲ. This showed that in the macula, electrical activity had weakened before the retina without visual or morphological changes, and with the development of the disease, the electrical activity decreased more obviously. CONCLUSlON:mf-ERG can evaluate the severity of DR, especially suit in the early and background period of DR.
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