维生素A棕榈酸酯眼用凝胶对烧伤后早期眼表修复的疗效观察

摘要

Abstract•AlM: To evaluate the clinical effect of vitamin A palmitate eye gel on early ocular surface reconstruction after thermal or chemical injuries.•METHODS: Seventy - eight cases with thermal or chemical injuries to eyes were selected and divided into two groups by randomized, double-blind, positive drug parallel controlled method: group A ( 40 cases were treated with vitamin A palmitate eye gel ) and group B [ 38 cases were treated with basic fibroblast growth factor ( bFGF ) ] . The bFGF and vitamin A palmitate eye gel were used 4 times a day. The treatment course was 14d. Restoration of epithelial defect, Schirmer’s test values, tear break-up time ( BUT) , and subjective assessment of symptoms and signs were observed on D1, D3, D5, D7, D10 and D14.•RESULTS: ln group A, 31 cases were cured, 5 cases were effective, with the cure rate of 76% and efficiency 90%. ln group B, 32 cases were cured, 3 cases were effective, with the cure rate of 84% and efficiency 92%. There were no significant differences between the two groups ( P > 0. 05 ). However, there were significant differences on the results of Schirmer’s test and BUT ( P<0. 05), those in group A were expanded compared with group B. Symptoms of dry eye, astringent and foreign body sensation of group A were significantly better than those of group B, there were significant differences ( P<0. 05).•CONCLUSlON:Vitamin A palmitate eye gel is valuable and safe on early ocular surface reconstruction of the eyes suffered from thermal or chemical injuries.%目的：：观察维生素A棕榈酸酯眼用凝胶对烧伤后早期眼表修复的临床疗效。方法：采用随机、双盲、阳性药物平行对照方法,将78例眼烧伤患者随机分为维生素A棕榈酸酯眼用凝胶治疗组( A组,40例),碱性成纤维细胞生长因子( bFGF)滴眼液治疗组( B 组,38例)。维生素 A 棕榈酸酯眼用凝胶和bFGF滴眼液均点眼4次/d,疗程为14d,观察两组的角膜上皮修复情况、干眼检查结果、症状及体征评分等指标。结果：维生素A棕榈酸酯眼用凝胶治疗组痊愈31例,显效5例,痊愈率为76%,有效率90%； bFGF治疗组痊愈32例,显效3例,痊愈率为84%,有效率为92%,两组之间无统计学差异(P >0.05),但维生素A棕榈酸酯眼用凝胶治疗组的Schirmer实验结果、泪膜破裂时间( BUT )与bFGF治疗组相比,均延长,两组之间有统计学差异( P<0.05)；而且维生素A棕榈酸酯眼用凝胶治疗组患者的眼干、涩以及异物感的症状减轻程度明显好于bFGF治疗组,两者之间有统计学差异(P<0.05)。结论：维生素A棕榈酸酯眼用凝胶对烧伤后早期眼表修复疗效确切、应用方便。