目的:观察外伤性视神经挫伤后应用鼠神经生长因子治疗疗效,评价该药的治疗效果.方法:选取2012-01/2016-01收治的外伤性视神经挫伤患者48例50眼进行回顾性研究,随机分为两组,治疗组24例24眼,对照组24例26眼;治疗组主要应用鼠神经生长因子30μg,每日1次,肌肉注射,用药6wk,同时给以高压氧舱、糖皮质激素类及维生素类药物;对照组除不加用鼠神经生长因子外,其余治疗同治疗组.所有患者均在用药后6wk复查视力、视觉诱发电位(visual evoked potential,VEP)、平均光敏感度(mean sensitivity,MS)、视野平均缺损(mean deviation,MD).结果:用药6wk后,治疗组与对照组最佳矫正视力比较,差异有统计学意义(P＜0.05);治疗组VEP P100波潜伏期为98.76±6.93ms、振幅5.22±1.64μV,对照组分别为116.52±8.82ms、4.28±1.75μV,两组间差异均有统计学意义(P＜0.05);治疗组与对照组MS、MD比较,差异均有统计学意义(P＜0.05).结论:外伤性视神经挫伤应用鼠神经生长因子治疗后,有更为明显的疗效.%AIM:To observe the effect of nerve growth factor treatment on traumatic optic nerve contusion and evaluate its therapeutic effect.METHODS:From January 2012 to January 2016,48 cases (50 eyes) with optic nerve contusion were treated.Retrospective study was carried out and the patients were randomly divided into two groups,treatment group 24 cases of 24 eyes,26 eyes of 24 cases in the control group;the treatment group mainly used mouse nerve growth factor injection 30μg,1 times daily intramuscular injection of medication,6wk,with the application of high pressure hyperbaric oxygen therapy,glucocorticoid and vitamin treatment;the treatment of control group was the same as treatment group,but without the injection of mouse nerve growth factor.Visual acuity,visual evoked potential (VEP) and mean sensitivity (MS),and mean deviation (MD) were examined in all patients at 6wk after the treatment.RESULTS:After treated for 6wk,there were significant differences in the best corrected visual acuity (P＜ 0.05)between the two groups.VEP P100 latency of treatment group was 98.76±6.93ms,amplitude was 5.22±1.64μV,those of the control group were 116.52±8.82ms,4.28± 1.75μV,both significantly different between the two groups (P＜0.05).The differences on MS and MD were significant (P＜0.05).CONCLUSION:The treatment of traumatic optic nerve contusion with nerve growth factor injection has more obvious curative effect.
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