目的:探讨 茁1肾上腺素受体(adrenergic receptor,AR) R389G基因多态性与原发性开角型青光眼(primary open angle glaucoma,POAG)患者眼压变化的关系.方法:选取2015-01/2017-02我院初诊 POAG 患者100例,分别于每日6:00、12:00、18:00、24:00测量患者的眼压并计算均值.眼压均值>30mmHg 的患者作为 A 组(44例),眼压均值<30mmHg的患者作为B组(56例),对比两组患者的临床资料,并采用多因素Logistic回归分析法探讨茁1AR R389G 基因多态性与 POAG 患者眼压变化的关系.结果:A组患者的 GG 基因型频率(27.3%)与 B 组患者(8.9%)比较,差异具有统计学意义(P<0.05).A组患者的等位基因 G 频率(40.9%) 显著高于 B 组患者(18.8%),差异具有统计学意义(P<0.05).经多因素Logistic回归分析法分析,POAG患者的收缩压增高、茁1AR R389G等位基因G频率增高是POAG患者眼压增高的独立危险因素(P<0.05).结论:茁1AR R389G 基因多态性与 POAG 关系密切,是POAG患者眼压增高的独立危险因素.%AIM:To investigate the relationship between adrenergic receptor(AR) R389G gene polymorphism and changes in intraocular pressure in patients with primary open angle glaucoma (POAG). METHODS: We selected 100 patients with newly diagnosed POAG from January 2015 to February 2017 in our hospital. The patient's intraocular pressure was measured at 6:00, 12:00, 18:00, and 24:00 daily and the mean value was calculated. Patients with mean intraocular pressure >30mmHg were included in Group A (44 patients), patients with mean intraocular pressure <30mmHg were treated as Group B (56 patients). The clinical data of two groups of patients were compared, and multivariate Logistic regression analysis was used to investigate the relationship between β1AR R389G gene polymorphism and changes in intraocular pressure in patients with POAG. RESULTS: The frequency of GG genotype in Group A (27.3%) was significantly higher than that in Group B (8 9%) (P < 0. 05). The allele G frequency was significantly higher in Group A (40.9%) than in Group B (18.8%), with a statistically significant difference (P<0 05). By multivariate Logistic regression analysis, increased systolic blood pressure and increased frequency of β1AR R389G allele were independent risk factors for increased intraocular pressure in POAG patients (P <0 05). CONCLUSION: The β1AR R389G gene polymorphism is closely related to POAG and is an independent risk factor for increased intraocular pressure in patients with POAG.
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