精神分裂症患者口服奥氮平和氯氮平对糖及脂代谢的影响

摘要

Objective We study the side-effect of olanzapine and clozapine on theglucose metabolism and lipid metabolism in schizophrenic patients .Method 7 1 cases of hospitalized patients with schizophrenia(2 0 1 0 .3-2 0 1 0 .1 1 ) ,randomly divided into two groups were given clozapine and olanzapine treatment .Determination of Cholesterol ,triglyceride ,fasting glucose ,insulin and C peptides by Roche Modular P8 0 0 .Measured the height and weight to calculate body mass index .Determination of olanzapine ,clozapine and N -demethyl clozapine in plasma .Results Clozapine and olanzapine treatment for body mass index ,triglycerides ,insulin and c-peptide the influence of the difference was statistically significant(P<0 .05 ) ,there was no statistically significant differ-ence effect on blood sugar( P>0 .0 5 ) .Conclusion Clozapine and olanzapine have effect on glucose metabolism , lipid metabolism and body mass index ,but the influence of clozapine .We should pay attention to the changes of blood sugar and blood fat w hen using atypical psychotropic drugs in clinical practices .%目的：探讨精神分裂症患者服用奥氮平和氯氮平后对体重指数、糖代谢和脂代谢指标变化的影响。方法选取我院2010年3～11月71例住院精神分裂症患者，随机分成两组，分别给予氯氮平和奥氮平治疗。采用罗氏全自动生化分析仪检测患者的糖代谢和脂代谢指标以及测量患者身高、体重，计算体重指数。结果氯氮平和奥氮平治疗后对体重指数、甘油三脂、胰岛素和C肽的影响差异有统计学意义（P＜0.05），对血糖的影响差异无统计学意义（P＞0．05）。结论氯氮平与奥氮平对糖代谢、脂代谢和体重指数都有影响，但氯氮平影响相对较大，临床治疗过程中应注意监测糖脂代谢的变化。