糖尿病足2号方对气虚血瘀型脱疽患者血管内皮细胞功能变化的临床研究

摘要

目的:探讨糖尿病足2号方对气虚血瘀型脱疽患者血管内皮细胞功能变化的影响.方法:符合纳入标准的69例动脉硬化闭塞症(ASO)患者随机分为观察组(36例)与对照组(33例).对照组采用血塞通治疗,观察组联合使用血塞通与糖尿病足2号方,两组均治疗30天,观察两组患者临床疗效及治疗前后踝肱比值和VEGF水平的变化.结果:治疗后两组患者ABI和VEGF水平降低,且观察组优于对照组(P<0.05,P<0.01);观察组临床有效率100.00%,对照组有效率90.91%,观察组优于对照组(P<0.05).结论:血塞通与糖尿病足2号方联用可降低ASO患者ABI比值,下调VEGF水平,改善临床疗效.%Objective:To study No.2 Diabetic Foot Formula on the function of vascular endothelial cells in gangrene patients with qi deficiency and blood stasis.Method:69 patients with arteriosclerosis obliterans(ASO) were randomly divided into the observation group (36 cases) and the control group (33 cases).The control group was treated with Xuesaitong,whereas the observation group was treated with the combination of Xuesaitong and No.2 Diabetic Foot Formula.Clinical efficacy,ankle brachial index(ABI),and vascular endothelial growth factor(VEGF) were observed after 30 days treatment in both groups.Results:The levels of ABI and VEGF in both groups were decreased after treatment,and the levels in the observation group were significantly lower than those in the control group (P<0.05,P<0.01).The efficiency of the observation group was 100.00%,whereas the control group was 90.91%,which showed the observation group was better than the control group (P<0.05).Conclusion:No.2 Diabetic Foot Formula can reduce ABI and down-regulate VEGF to improve clinical efficacy for ASO patients.