CGI-58在动物脂类代谢中的作用

摘要

There are some proteins on the surfaces of lipid droplets (LDs) in the cells which could regulate the lipogene-sis and lipolysis, and play an important role in lipid metabolism of the whole body. Comparative gene identification-58 (CGI-58), distributing predominantly on the surface of LDs, which is a member of the α/β-hydrolase folding family and an activator of adipose triglyceride lipase (ATGL) and acyl-CoA-dependent lysophosphatidic acid acyltransfer (LPAAT). CGI-58 promotes lipolysis by combining with perilipin which is a member of the PAT family and ATGL. At the same time, the function of CGI-58 to activate ATGL is influenced by protein-protein interaction with the members of the perilipin fam-rnily.This paper reviews the CGI-58 function in lipid metabolism of animals considering the hot topics.%细胞中脂滴(Lipid droplets,LDs)表面存在多个调控脂肪储存和分解的蛋白,这些蛋白对机体的脂肪代谢 起着很重要的调控作用.CGI-58(Comparative gene identification-58)分布在LDs 表面,属于α/β水解酶折叠家族,是脂肪甘油三酯脂肪酶(Adipose triglyceride lipase,ATGL)和依赖酰基辅酶A 溶血磷脂酸酰基转移酶(Lysophosphatidic acid acyltransferase,LPAAT)的激活剂.在脂肪分解过程中,CGI-58 结合PAT 蛋白家族成员之一的 脂滴包被蛋白(Perlipin)和ATGL,促进脂肪分解,同时CGI-58 对ATGL 的激活功能受脂滴包被蛋白家族成员间 蛋白质与蛋白质相互作用的影响.文章结合国内外研究热点,针对CGI-58 在动物脂类代谢中的作用进行了综述.