Objective To observe the effect of rhubarb choleretic capsule on preventing gallstone recurrence after minimal invasive gallstone surgery. Methods Sixty patients with gallstone who received laparoscopic-choledochoscopy-assisted removal of cholecystolithotomy(LRCL)were divided into treatment group and control group.The treatment group was treated with rhubarb choleretic capsule after surgery,while the control group took no medicine. The patients were followed up and took B ultrasonic testing after surgery. The gallstonere currence rate,gallbladder wall thickness as well as gallbladder contraction efficiency were recorded. Results Compared with 2 days before operation,the gallbladder wall thickness were remarkably decreased in both groups(treatment group,t= 16.391,P<0.01;control group,t= 7.004,P<0.01),and the results were statistically significant.The gallbladder contraction ratios were markedly increased and there are statistically significant differences(treatment group,t= -42.817,P<0.01;control group,t= -23.066,P<0.01).Compared with the control group,the gallbladder wallthickness in rhubarb choleretic capsule treatment group decreased significantly(t = -7.813,P<0.01),while the gallbladder contraction ratio increased significantly(t= 12.693,P<0.01).The gallstone recurrence rate of the treatment group were obviously lower than the control group( χ2 = 4.32,P< 0.05),the results were significant. Conclusion There is a positive effect of taking rhubarb choleretic capsule after minimal invasive gallstone surgery to prevent the gallstone recurrence.%目的：观察大黄利胆胶囊预防微创保胆取石术后胆囊结石复发的疗效。方法将60例行腹腔镜胆道镜微创保胆取石术（LRCL）的胆囊结石患者分治疗组和对照组各30例，治疗组术后给予大黄利胆胶囊，对照组不服用任何药物。术后定期对患者进行随访，并行 B 超检测，观察患者术后胆囊结石复发率、胆囊壁厚度和胆囊收缩率。结果与术前2 d 相比，治疗组和对照组患者术后胆囊壁厚度均明显减小（治疗组，t=16.391，P<0.01；对照组，t =7.004，P<0.01），差异有统计学意义；胆囊收缩率明显增加（治疗组，t=-42.817，P<0.01；对照组，t=-23.066，P<0.01），差异有统计学意义。与对照组比较，治疗组患者胆囊壁厚度明显减小（t=-7.813，P<0.01）、胆囊收缩率明显增加（t =12.693，P<0.01），差异有统计学意义；治疗组患者结石复发例数明显少于对照组（χ2=4.32，P<0.05），差异有统计学意义。结论术后服用大黄利胆胶囊对预防 LRCL 术后胆囊结石复发具有积极作用。
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