目的：了解国际临床药学服务的演进路径、研究进展和最新热点。方法研究对象纳入2000—2015年Web of Science核心合集数据库中收录的主题为“临床药学服务”的文献，应用CiteSpace知识可视化软件绘制文献同被引网络图谱，析出关键节点文献；并应用其同被引聚类和突变探测功能分析研究热点与前沿。结果确定了文献增长的时间分布、载文期刊分布和国家与研究机构分布，以及能够展示临床药学服务研究演进路径的关键节点文献、聚类群以及表征研究热点与前沿的突变词和突变文献。结论国际临床药学服务领域的研究热点主要集中在三个方面：①实践，包括临床药学服务在临床中的服务模式和服务内容，及其在急诊、器官移植、心血管和糖尿病等不同疾病中的具体干预措施、临床药学服务开展的情况调查、基于基因类型的个体化用药指导以及远程药学服务等；②评价，包括对药师干预措施的效果评价，服务质量评价，药物经济学评价等；③药师职业发展，包括药师培养模式、资质认证、住院药师制度、工作满意度等。%Objective To reveal the evolution, research hotspots and research fronts of clinical pharmacy services. Methods Documents related to "clinical pharmacy services" from 2000 to 2015 in Web of Science Core Collection database are included.Documents are visually analyzed through a number of co-citation maps, which identified the critical node documents in the revolution of clinical pharmacy services research by knowledge visualization tool, CiteSpace. Its functions of clustering and burst terms detection were also applied to analyze the research hotspots and research fronts. Results This paper determined the distribution of documents on time period, journals, countries and research institutions. Critical node documents perfectly showed the evolution pathway of clinical pharmacy services, main cluster groups and burst terms and documents, indicating the research hotspots and research fronts. Conclusion The research hotspots focus on 3 aspects.1 .Practice, including the service model and content of clinical pharmacy services;its interventions in diseases of emergency, organ transplantation, cardiovascular disea-ses and diabetes;surveys on developing clinical pharmacy services;genotype-guided individualized dosing;remote pharmacy serv-ices.2.Evaluation, including the assessment of the effects of pharmacists' interventions, service quality evaluation, and pharmaco-economic evaluation.3.Pharmacists' career development, including Pharmacists' training pattern, qualification, pharmacy residen-cy programs and job satisfaction.
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