锦花清热胶囊抗炎镇咳镇痛作用研究

摘要

Objective To study the anti-inflammatory,antitussive,and analgesia effects of Jinhua qingre capsules.Methods The anti-inflammatory effect was assessed by the methods include xylene-induced mouse auricular swelling and histamine-induced pigment oozing from skin vessel in rats;The antitussive and analgesic effect were assessed by ammonia water induced cough model and acetic acid-induced twisting method.Results In anti-inflammation experiment,the high dose (12 g·kg-1) and moderate (6 g·kg-1) groups of Jinhua qingre capsules showed significant inhibitory effect on auricular swelling and significant difference compared with control group (P ＜ 0.01,P ＜ 0.05.);the high dose (10 g· kg-1) and moderate dose (5 g·kg-1) groups of Jinhua Qingre capsules play a marked inhibitory role in the increase in mouse peritoneal capillary permeability (P ＜ 0.01,P ＜ 0.05).In antitussive experiment,high dose (12 g· kg-1) and moderate dose (6 g· kg-1) groups had significant inhibitory effect on cough caused by ammonia water (P ＜ 0.01,P ＜ 0.05) compared with control group.In analgesic experiment,the high dose (12 g·kg-1),moderate dose (6 g·kg-1),and low dose (3 g·kg-1) groups effectively reduced the writhing frequency of mice (P ＜ 0.01,P ＜ 0.05).Conclusion Jinhua qingre capsules have potential effects on anti-inflammatory,antitussive,and analgesic.%目的 研究锦花清热胶囊抗炎、镇咳和镇痛作用.方法 采用二甲苯致小鼠耳肿胀实验、磷酸组胺致大鼠皮内色素渗出实验观察锦花清热胶囊内容物的抗炎活性;采用氨水致小鼠咳嗽实验、冰醋酸致小鼠扭体实验观察锦花清热胶囊内容物对小鼠的镇咳和镇痛作用.结果 抗炎实验结果显示,大剂量(12 g·kg-1)、中剂量(6 g·kg-1)锦花清热胶囊内容物对二甲苯致小鼠耳肿胀有明显的抑制作用(P＜0.01,P＜0.05);大剂量(10 g·kg-1)、中剂量(5 g·kg-1)锦花清热胶囊内容物对磷酸组胺致大鼠皮内色素渗出有明显的抑制作用(P＜0.01,P＜0.05).镇咳实验结果显示,大剂量(12g·kg-1)、中剂量(6 g·kg-1)锦花清热胶囊内容物对氨水致小鼠咳嗽有明显抑制作用(P ＜0.01,P＜0.05).镇痛实验结果显示,大剂量(12 g·kg-1)、中剂量(6 g·kg-1)、小剂量(3 g·kg-1)锦花清热胶囊内容物对醋酸致小鼠扭体次数有明显抑制作用(P＜0.01,P＜0.05).结论 锦花清热胶囊具有较好的抗炎、镇咳和镇痛作用.