天蟾胶囊治疗轻、中度癌性疼痛241例有效性与安全性的临床观察

摘要

目的：观察天蟾胶囊治疗癌痛的疗效与安全性。方法：选择241例轻、中度癌痛患者，接受天蟾胶囊单用或联合三阶梯药物治疗4周，观察天蟾胶囊的镇痛效果及安全性。结果：天蟾胶囊治疗癌性疼痛平均起效时间约为2.5±0.8小时，服药一周达到稳定的镇痛效果，对躯体痛、内脏痛、神经病理性疼痛的疼痛缓解率分别为69.8%、72.6%、67.6%，对不同类型的癌痛作用无显著性差异，用药期间发生的不良反应主要是恶心、食欲不振等胃肠道反应，程度轻微，未影响继续治疗。结论：天蟾胶囊治疗癌性疼痛疗效确切，与三阶梯镇痛药物合用具有协同作用，不良反应发生率低，安全性好。%Objective:To evaluate the efficacy and safety of Tianchan capsule in the treatment of cancer pain. Methods:A total of 241 patients with mild and moderate cancer pain have received Tianchancapsule alone or combined with three ladders analgesia for 4 weeks. Results:The average working time of Tianchan capsule was about 2.5 ± 0.8 hours and reached stable analgesic effect after treatment for one week. The relief rate of body pain, visceral pain, and neuropathic pain was 69.8%, 72.6%and 69.8%respectively, there was no significant difference between the different types of pain,Duringmedication period ,The adverse reactions of Tianchan capsule was low , mainly showed gastrointestinal reaction, such as nausea, loss of appetite,it does not influence follow-up care. Con-clusion:Tianchan capsule is safe and effective in the treatment of cancer pain, as well as synergistic action with three ladders analge-sia combination therapy.