维生素E防治大肠癌患者急性化疗性肝损伤的疗效分析

摘要

目的：探究维生素E对大肠癌化疗所致急性肝损伤的防治效果。方法筛选192例符合要求的大肠癌化疗患者，按1∶1比例随机分为治疗组（维生素E：500 mg／d）及空白对照组，观察两组发生化疗性肝损伤的机率及程度。另收集化疗引起肝损伤的大肠癌患者57例，按1∶1比例随机分组，分别给予复方甘草酸单铵S （160 mg／d）单用或联合维生素E （500 mg／d）治疗，观察两组的肝功能恢复情况和不良反应。结果在预防肝损伤的试验中，应用维生素E降低了肝损伤的发生率，结果有统计意义。在治疗肝损伤的试验中，复方甘草酸单铵S单用或联合维生素E治疗化疗性肝损伤效果显著，但单药治疗与联合治疗组间治疗效果没有差别。结论维生素E对预防化疗引起的急性肝功能损伤有作用，但在治疗化疗性肝损伤中的作用还不明确。%Objective To evaluate the efficacy of vitamin E on the prevention and treatment of chemotherapy -induced hepatic injury (CIHI).Methods 192eligiblepatientswererandomlydividedintotheratioof1:1intothetreatmentgroup(vitaminE500mg/d)and the control group.The probability and degree of hepatic injury between the two groups were evaluated .In addition, 57 CIHI patients were divided equally to receive compound ammonium glycyrrhetate S for injection (160 mg/d) with vitamin E (500 mg/d) or compound ammoni-um glycyrrhetate S for injection (160 mg/d) alone.After treatment, the liver function and the adverse reaction were evaluated .Results In the prevention study , the incidence rate of CIHI in the treatment group is reduced by vitamin E .In the treatment assay , for CIHI pa-tients, there is no difference between compound ammonium glycyrrhetate S alone and compound ammonium glycyrrhetate S with vitamin E . Conclusion Vitamin E can reduce the incidence rate of CIHI .But the role of vitamin E in the treatment of CIHI is not well defined .