复方人参颗粒剂的制备工艺及活性研究

摘要

In order to obtain stable ,effective and controllable preparation process of compound ginseng granules , taking Panax ginseng ,Fructus schisandrae and Lycium barbarum as raw materials .The orthogonal experiment was adopted by wet granulation and taking content of ginsenoside Re and qualification rate of granules as stand‐ard to assess the quality .The anti‐fatigue and hypoxia tolerance activity of the granules were also assayed .The results showed that the best preparation process were confirmed that the ratio of materials with adjuvant at 1∶2 under the condition that three materials at 1 .0∶1 .0∶1 .5 ,soluble starch ,dextrin ,and sugar at 1∶2∶2 proportion , dried at 60℃ .Pharmacology experiments showed that 6 .4 mg・mL‐1 dose groups of the granules exhibited sig‐nificant anti‐fatigue and hypoxia tolerance activity .The processes were proved with stability ,practicality and reproducibility character ,the granules exhibited certain health functions .%为制备工艺稳定、有效可控的复方人参颗粒剂，以人参、北五味子、枸杞为原料，运用正交试验方法，采用湿法制粒，以人参皂苷Re的含量，颗粒剂的合格率为指标，优选复方人参颗粒剂制备工艺。并对制备颗粒剂的抗疲劳和常压耐缺氧活性进行测定。结果表明：3种原料药配比为1．0∶1．0∶1．5，可溶性淀粉、糊精和蔗糖配比为1∶2∶2，原料药与辅料的配比为1∶2，干燥温度为60℃时，为最佳制备工艺。药理实验结果表明，6．4 mg・mL‐1剂量的颗粒剂溶液可显著提高小鼠的抗疲劳及常压耐缺氧能力。制备工艺稳定性强，具有可操作性和重现性，制备的颗粒剂具有一定保健功能。