冠心病患者焦虑障碍与超敏C反应蛋白的关系探讨

摘要

Objective: To evaluate the general anxiety disorder ( GAD) in coronary heart disease (CHD) patients, in addition to cardiac biomarkers such as high-sensitivity C-reactive protein (hs-CRP) ,troponin T(TnT) , and brain natriuretic peptide (BNP). Method: The study included 60 CHD patients with GAD in observing group and 60 CHD patients without psychiatric disorder in control group. All cases were given cardiac biomarkers tests such as hs-CRP, TnT and BNP. Result: There were no significant difference between two groups on TnT and BNP level (P＞0.05). Hs-CRP levels in observing group were much higher than those in control group. Regression analyses showed an association between GAD and hs-CRP levels. Conclusion: Significant associations between anxiety and CHD risk, with a potential biologic link between anxiety and elevations in hs-CRP level enhances the approach of multidisciplinary care of CHD patients, including screening and treatment of heightened anxiety disorders.%目的:研究冠心痛合并广泛性焦虑(GAD)的患者血清超敏c反应蛋白(hsC RP)、肌钙蛋白T (TnT),和血浆脑钠肽(BNP)的变化,探讨其相关性.方法:60例冠心病合并GAD作观察组,无心理障碍的冠心痛患者60例为对照组,进行hsCRP、TnT、BNP的检测.结果:两组在TnT和BNP水平上无显著性差异(P＞0.05).观察组hsCRP水平上显著高于对照组,其差异具有统计学意义(P=0.002)；经多因素逐步回归分析,hsCRP与冠心病合并GAD焦虑密切相关.结论:hsCRP水平与冠心 病合并焦虑障碍显著相关,应重视冠心痛患者多学科的综合诊治,焦虑情绪的识别和治疗.