Objective: In order to investigate the elimination effect and curative effect of propofol on reactive oxygen species in patients with acute craniocerebral injury. Method: We used electron spin resonance spectroscopy to determine the plasma contents of oxygen free radical, and the chemical-high performance liquid chromatography were used to determine the nitrogen oxide and plasma contents of lipid peroxides . And then investigated the elimination effect and curative effect of propofol on reactive oxygen species in patients with acute craniocerebral injury. Result: Except of the nitrogen oxide in 2 hours after starting operation, every indexes in 2 and 4 hours after starting operation were lower, there were difference between the performance(P<0. 05). Conclusion: Propofol can clear the reactive oxygen species in patients with acute craniocerebral injury, and lessen the risk of secondary cerebral injury.%目的:分析丙泊酚对急性颅脑损伤患者体内活性氧的消除作用及效果.方法:分别采用电子自旋共振法及化学发光-高效液相色谱法,测定43例急性颅脑损伤患者手术前后血内氧自由基,一氧化氮、脂质过氧化物含量,分析丙泊酚对急性颅脑损伤患者体内活性氧的清除作用及效果.结果:除开颅去骨瓣2 h一氧化碳检测均值外,开颅手术去骨辩2h及4h各项指标与麻醉诱导前相比均有显著性降低,差异均有统计学意义(P≤0.05).结论:丙泊酚能够有效清除急性颅脑损伤患者体内活性氧,降低继发性脑缺血再灌注损害的发病风险.
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