不同血管活性药物在感染性休克治疗中的临床应用

摘要

目的:观察不同血管活性药物在治疗感染性休克的临床应用.方法:2009年1月至2010年12月,选取我院90例感染性休克患者,随机分成三组,每组分别应用多巴胺、多巴胺加间羟胺、去氧肾上腺素加多巴酚丁胺治疗,观察治疗后血液动力学变化情况和肾功能的改变情况.结果:统计学分析结果显示,与基础值比较,三组患者用药后平均动脉压(MAP)、心脏排血指数(CI)均明显升高；A组和C组尿量明显多于基础值(P＜0.05)；Ccr值C组明显高于基础值和其它各组(P＜0.05).结论:血管活性药物能明显改善感染性休克患者的血液动力学和肾功能,临床疗效确切,但不同血管活性药物临床疗效存在不同的临床差异.%Objective: To observe the clinical applications of different vasoactive drugs with septic shock. Method: From Jan. 2009 to Dec. 2010, 90 cases of patients selected in our hospital with septic shock were randomly divided into three groups, respectively, dopamine, dopamine plus metaraminol, pheny-lephrine plus dobutamine for treatment. After treatment, hemodynamic changes and renal function changes, were observed. Result: Compared with baseline, 3 groups of patients mean arterial pressure (MAP) , cardiac ejection index ( CI) increased significantly after treatment; group A and group C was higher than the baseline urine (P<0.05); Ccr was significantly higher than the base value of C value and the other groups (P <0.05). Conclusion: Vasoactive drugs can significantly improve patients with septic shock and renal hemodynamics, clinical efficacy, but the clinical efficacy of different vasoactive drugs are different.