The Evaluation of Vasoactive Agents in Shock with and in the Absence of Intravenous Fluid Therapy

摘要

The report deals with the following areas of study related to vasoactive agents and fluid therapy in shock: (1) The effects of beta-adrenergic receptor stimulation on blood flow, oxidative metabolism and survival in hemorrhagic shock (dose--response relationships in differing circumstances, survival studies with continuous Isoproterenol infusion, oxygen consumption and excess lactate with Isoproterenol); (2) Hepato-splanchnic lymph production with hydrocortisone treated endotoxin shock; (3) The ventilatory response to hemorrhage (alterations in the response of ventilation to carbon dioxide, studies in awake animals, carotid sinus denervation and vagal-sympathetic trunk division); (4) Dynamic alterations in the volume of distribution of anions in hemorrhagic hypotension and hypoxemia; (5) The hemodynamic and metabolic effects of lactated Ringer's solution in hemorrhagic shock.