不同浓度丙泊酚复合氯胺酮在小儿全身麻醉中的应用

摘要

Objective:To study the efficacy and safety of different concentrations of propofol combined with ketamine in the children with general anesthesia. Method:75 children with elective surgery from Feb. 2009 to Aug. 2011 in our hospital were randomly divided into three group. They were given 0. 5% (group A) , 0.7% (group B) , and 0.9 % (group C) of propofol combined with ketamine anesthesia respectively. The operative time, recovery time, mean arterial pressure (MAP) , heart rate value (HR) , post-operative cough, vomiting, respiratory depression and other adverse reactions were analyzed. Result:The MAP, HR in group C were significantly lower than group A and group B (P<0.05) ,The recovery time in group C was shorter than the other groups (P<0.05) ; The rates of nausea, vomiting, respiratory depression and other adverse reactions were lower than the other groups (P<0.05). Conclusion:0.9% of the propofol combined with ketamine has good efficacy to the children with general anesthesia, it can reduce the adverse reactions when it applied alone, and it is worth to be applied in clinical.%目的:探讨不同浓度丙泊酚复合氯胺酮在小儿全身麻醉中的临床效果和安全性.方法:将2009 年2 月至2011 年8 月于我院住院择期外科手术的患儿75 例随机分为三组,分别采用三种浓度0.5%(A 组)、0.7%(B 组)、0.9%(C 组)的丙泊酚复合氯胺酮进行全身麻醉.对患儿手术时间、苏醒时间,手术过程中平均动脉压值(MAP)、心率(HR),手术后咳嗽、呕吐、呼吸抑制等不良反应等进行统计分析.结果:C 组患儿MAP 、HR 值明显低于A 组和B 组(P＜0.05),苏醒时间明显短于其他两组(P＜0.05),恶心、呕吐、呼吸抑制等不良反应发生率也明显低于其他两组(P＜0.05).结论:0.9%的丙泊酚复合氯胺酮对患儿全身麻醉效果确切,能减少单独应用时的不良反应,值得推广应用.