通心络胶囊治疗72例糖尿病心肌病的临床观察

摘要

目的：探讨通心络胶囊佐治糖尿病心肌病的药物疗效。方法：将纳入对照研究的72例糖尿病心肌病患者按随机数字表法分成2组：对照组36例给予降血糖、降血压、调脂等常规治疗；观察组36例再口服通心络胶囊治疗。比较两组血糖水平、血液流变学、心脏结构及功能参数值的变化情况。结果：观察组治疗后的FBG、PBG、HbA1c血糖指标水平优于对照组（ P＜0．05）；观察组治疗后的ηb、ηp、Fg血液流变学指标水平的改善程度比对照组显著（ P＜0．05）；观察组治疗后的LAd、LVEDd、IVSd、LVPWd心脏结构指标水平和 EF、FS、PE、PA、E／A 心脏功能指标水平明显优于对照组（ P＜0．05）。结论：通心络胶囊佐治糖尿病心肌病能够改善血液流变学和心肌重构，促进心脏功能恢复和提高。%Objective:To investigate the efficacy of Tongxinluo capsule in the treatment of diabetic car-diomyopathy .Method:72 cases of diabetic cardiomyopathy patients were randomly divided into two groups , control group (n=36) and observation group (n=36), the control group was given lower blood sugar , blood pressure , lipid and other conventional treatment , and the observation group was given Tongxinluo capsule . The parameter of blood sugar levels , blood rheology , cardiac structure and function in 2 groups was com-pared.Result:After 4 weeks of treatment, the level of FBG,PBG,HbA1c in the observation group was sig-nificantly better than the control group ( P<0.05); the degree of improvement hemorheology about ηb, ηp and Fg in the observation group was significantly higher than the control group ( P<0.05);the cardiac struc-ture parameters about LAd,LVEDd,IVSd,LVPWd and the cardiac function parameters about EF ,FS,PE, PA,E/A in the observation group was significantly better than the control group (P<0.05).Conclusion:Tongxinluo capsule in the treatment of diabetic cardiomyopathy can improve blood rheology and myocardial remodeling , and promote recovery and improve heart function .