喜炎平注射液联合氨茶碱对慢性支气管炎急性发作患者血气指标及血清TNF-αIL-8 IL-10水平的影响

摘要

目的:探讨喜炎平注射液联合氨茶碱(Ami)对慢性支气管炎急性发作(AECB)患者血气指标及血清TNF-α、IL-8、IL-10水平的影响.方法:选择2015年4月至2017年4月接受治疗的AECB患者142例,采用简单随机法均分为两组.对照组给予 Ami 治疗,观察组在此基础上联合喜炎平注射液治疗.记录和比较两组治疗前后血气指标、血清TNF-α、IL-8、IL-10水平的变化、临床疗效及不良反应的发生情况.结果:治疗后,患者 PaO2值显著升高,PaCO2值显著降低(P<0.01),且观察组 PaO2值明显高于对照组,PaCO2值显著低于对照组(P<0.01).治疗后,患者血清 TNF-α、IL-8水平均显著下降,IL-10水平均显著升高(P<0.01),且观察组 TNF-α、IL-8水平显著低于对照组,IL-10水平显著高于对照组(P<0.01).治疗后,观察组总有效率较明显高于对照组(P<0.05).两组不良反应发生率比较无统计学意义(P>0.05).结论:喜炎平注射液联合氨茶碱治疗慢性支气管炎急性发作更能迅速改善患者肺功能、提高临床疗效,可能与其显著降低血清TNF-α、IL-8水平并提高血清 IL-10水平,抑制机体炎症反应、提高免疫功能有关.%Objective: To investigate the effect of Xiyanping injection combined with aminophylline (Ami) on the blood gas index and serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-8 and IL-10 of patients with acute exacerbation of chronic bronchitis (AECB). Methods: 142 cases of AECB pa-tients admitted in our hospital from April 2015 to April 2017 were selected. According to simple random meth-od,those patients were divided into two groups. The control group was treated with Ami while the observation group was given the combination of Ami and Xiyanping injection. The changes of blood gas indexes, serum TNF-α,IL-8,IL-10 levels before and after treatment,clinical effect as well as the incidence of adverse re-actions were compared between the two groups. Results: After treatment, the value of PaO2 was significantly increased,and the PaCO2 value decreased significantly(P< 0.01),the PaO2in observation group was higher than that in the control group,and PaCO2was less than that in the control group(P< 0.01). After treatment, TNF-α,IL-8 in the serum of the patients were significantly decreased,and the levels of IL-10 were signifi-cantly increased(P< 0.01),TNF-α,IL-8 in the observation group were less than the control group,IL-10 was higher than the control group(P< 0.01). After treatment,the total effective rate of observation group was higher than the control group (P< 0.05). The incidence of adverse reactions was not statistically significant (P>0.05). Conclusion: Xiyanping injection combined with aminophylline treatment of chronic bronchitis a-cute episodes can rapidly improve the patients'lung function,improve clinical curative effect,to significantly reduce the level of serum TNF alpha,IL - 8 and raise the level of serum IL - 10,inhibit the body's inflam-matory response and improve immune function.