血浆脑利钠肽在小儿川崎病中的变化及其与心功能的相关性分析

摘要

目的:探讨血浆脑利钠肽在小儿川崎病中的变化及其与心功能的相关性.方法:将2015年7月至2017年7月我院收治的川崎病患儿39例作为观察组,根据病情分为急性期患儿20例,恢复期患儿19例;另将同期在我院进行健康体检的儿童50例作为对照组,检测两组血浆脑利钠肽水平,同时检测观察组各项心功能指标,分析患儿血浆脑利钠肽水平与心功能相关性.结果:急性期患儿血浆脑利钠肽水平明显高于恢复期和对照组,差异有统计学意义(P<0.05);恢复期患儿血浆脑利钠肽水平高于对照组,差异有统计学意义(P<0.05);急性期患儿LVSF、CI、LVEF指标明显低于恢复期,差异有统计学意义(P<0.05);急性期患儿E/A指标与恢复期比较,差异无统计学意义(P>0.05);血浆脑利钠肽水平与急性期患儿LVSF、CI、LVEF指标呈现明显负相关(P<0.05),与E/A指标无明显相关性(P>0.05).结论:川崎病急性期患儿血浆脑利钠肽水平明显上升,与LVSF、CI、LVEF 呈负相关,对于患儿临床早期诊断至关重要.%Objective: To investigate the changes of plasma brain natriuretic peptide in children with Kawasaki disease and its correlation with cardiac function. Methods:From July 2015 to July 2017 in our hos-pital,39 cases of pediatric children with Kawasaki disease as the observation group,according to the disease is divided into 20 cases of acute children,19 cases of convalescent patients; the same period in our hospital 50 cases of healthy children as a control group. The levels of plasma brain natriuretic peptide were detected in the two groups.Meanwhile,the cardiac function indexes in the observation group were also examined.The cor-relation between plasma brain natriuretic peptide and cardiac function was analyzed. Results: The levels of plasma brain natriuretic peptide in acute stage were significantly higher than those in recovery stage and control group (P <0.05). The level of plasma natriuretic peptide in convalescent group was higher than that in control group,the difference was statistically significant (P <0.05).The indexes of LVSF, CI, LVEF in acute stage were significantly lower than those in recovery stage, the difference was statistically significant (P <0.05). The difference of E / A index and recovery period There was no significant difference between the two groups (P> 0.05). Sodium levels of plasma brain natriuretic peptide and children with acute LVSF,CI,LVEF indi-cators show a significant negative correlation (P <0.05), and E/A showed no significant correlation (P> 0. 05). Conclusion:The level of plasma brain natriuretic peptide in children with acute Kawasaki disease is sig-nificantly increased,which is negatively correlated with LVSF,CI and LVEF,which is of great importance for early clinical diagnosis in children.