VEGF和PTEN在上皮性卵巢癌中的表达及意义

摘要

Objective To investigate the role of VEGF and PTEN in the pathogenesis and development of epithelial ovarian cancer, and to explore the correlation between them. Methods The expressions of VEGF and PTEN in 60 cases of epithelial ovarian carcinoma,20 cases of benign ovarian tumors and 20 cases of normal ovarian tissue were detected by immunohistochemistry( SP ). Results The expression levels of VEGF in epithelial ovarian cancers tissue were obviously higher than those in benign ovarian tumors and normal ovarian tissue( P <0. 05 ). In ovarian cancer group, the expression levels of VEGF at FIGO IH , IV stage or in lymph node metastasis group were significantly higher than those in FIGO I , II stage or in no lymph node metastasis group( P < 0. 05 ), and the expression levels of VEGF in high-degree and middle-degree differentiation groups were significantly higher than those of poor differentiation group( P <0. 05 ),and the expression of VEGF was positively correlated with that of PTEN( r =0.297, P <0.05 ). Conclusion The overexpression of VEGF and the deletion of expression of PTEN protein may result in the out of control of cell proliferation, and the two kinds of proteins may cooperatively promote the pathogenesis, development and metastasis of ovarian cancer.%目的 探讨VEGF和PTEN蛋白表达在上皮性卵巢癌的发生、发展中的作用及相关性.方法 采用免疫组织化学S-P法检测60例卵巢上皮性癌,20例卵巢良性肿瘤和20例正常卵巢组织中VEGF和PTEN的表达.结果 VEGF在上皮性卵巢癌组织的阳性表达率明显高于卵巢良性肿瘤组织和正常卵巢组织(P<0.05),在恶性肿瘤组中临床Ⅲ/Ⅳ期较Ⅰ/Ⅱ期、有淋巴结转移组较无淋巴结转移组VEGF表达增强(P<0.05),低分化组明显高于高中分化组(P<0.05);卵巢癌组织中PTEN表达状况明显低于卵巢良性肿瘤(P<0.05),正常卵巢组织中均表达PTEN.在恶性肿瘤组中,VEGF在临床Ⅰ、Ⅱ期表达明显高于Ⅲ、Ⅳ期,在无淋巴结转移组明显高于有淋巴结转移组(P<0.05),高中分化组明显高于于低分化组(P<0.05),VEGF和PTEN表达呈正相关(r=0.297,P=0.029).结论 VEGF过表达和PTEN蛋白表达的缺失可能导致细胞增殖失控,这两种蛋白可能共同促进卵巢癌的发生、发展、浸润及转移.