贝前列素联合西地那非对COPD合并肺动脉高压的临床研究

摘要

Objective To investigate the therapeutic effects of beraprost combined with sildenafil on chronic obstructive lung disease ( COPD) complicated by pulmonary hypertension .Methods Eighty patients with COPD complicated by pulmonary hypertension who were treated in our hospital from June 2014 to December 2015 were randomly divided into control group,beraprost group,sildenafil group,combination medication group (beraprost+sildenafil),with 20 patients in each group.The therapeutic effects on 1,3,6 months after treatment were observed and compared among the four groups .Results After treatment , the exercise tolerance of patients in beraprost group , sildenafil group , combination medication group was significantly improved,moreover,the blood gas analysis parameters,hemorheology indexes,myocardial enzyme indexes,plasma brain natriuretic peptide (BNP),left ventricular ejection fraction (LVEF),right atrial pressure,left ventricular size,PAP, 6-min walking distance and lung function were significantly improved in the three groups ( P <0.05 ) .Conclusion The beraprost combined with sildenafil can decrease disease attack frequency ,reduce death rate and improve life quality of patients with COPD complicated by pulmonary hypertension ,thus,which has better social and economic effects .%目的 探究患有慢性阻塞性肺疾病(COPD)合并肺动脉高压的患者使用贝前列素与西地那非联合治疗方案的临床效果.方法 选取2014年6月至2015年12月收集住院的COPD合并肺动脉高压的患者80例,采用随机分组法分为对照组、贝前列素组、西地那非组、贝前列素与西地那非联合用药组,每组20例;对比分析4组患者接受治疗后1、3、6个月的治疗效果.结果 贝前列素组、西地那非组与联合治疗组患者经过治疗运动耐力显著提高,患者的血气分析、血液流变性指标、心肌酶指标、血浆脑钠素(BNP)、左心室射血分数(LVEF)、右心房压、左右心室大小、PAP、6 min步行距离、肺功能检查均有明显改善.结论 通过使用两种联合药物作用的疗效的评估,可以一定程度降低COPD合并肺动脉高压患者的发病次数,降低其病死率,提高生活质量,具有较好的社会经济效应.