五水头孢唑林钠联合热淋清颗粒在治疗肾结石术后泌尿系感染中的作用

摘要

Objective To investigate the therapeutic effects of cefazolin sodium pentahydrate combined with Reqinglin granules on urinary system infection after renal calculi surgery.Methods Seventy-six patients with urinary system infection after renal calculi surgery were randomly divided into control group (n=38) and observation group (n=38).The patients in control group were treated with cefazolin sodium pentahydrate by intravenous drip,2g/time,once a day,however,the patients in observation group,on the basis of control group,were treated by Reqinglin granules,2 bags/time,3 times a day,continuously for 7 days.The therapeutic effects after treatment, bacterial eradication rate and renal function related indexes including creatinine (Cr),urea nitrogen (UN),microalbuminuria (DMII) and oxidative stress proteins NOX2,NOX4,DUOX1 were observed and compared between two groups before and after treatment.Results The therapeutic effects and bacterial eradication rate in observation group were superior to those in control group (P<0.05).After treatment the levels of Cr,UN,SOD in observation group were significantly higher than those in control group (P<0.05).However there were no significant differences in the levels of DMII, MDA, NOX2, NOX4 and DUOX1protein between two groups (P>0.05).Conclusion The therapeutic effects of cefazolin sodium pentahydrate combined with Reqinglin granules on urinary system infection after renal calculi surgery are superior to those of cefazolin sodium pentahydrate only,thus,which is worth using widely in clinical practice.%目的 探讨五水头孢唑林钠联合热淋清颗粒在治疗肾结石术后泌尿系感染中的作用.方法 将泌尿外科收治的76例肾结石术后泌尿系感染患者随机分为对照组和观察组,每组38例.对照组静脉滴注给予五水头孢唑林钠2.0 g,1次/d,观察组在对照组基础上给予热淋清颗粒,2袋/次,3次/d,连续用药7 d.比较2组患者治疗前后临床疗效、细菌清除率及肾功能相关指标肌酐(Cr)、尿素氮(UN)及微量蛋白尿(DMII)水平及氧化应激蛋白 NOX2、NOX4及DUOX1蛋白水平.结果 观察组临床疗效和细菌清除率显著优于对照组(P<0.05);此外,观察组治疗后Cr、UN水平显著高于对照组治疗后(P<0.05);观察组治疗后SOD水平显著高于对照组治疗后(P<0.05);观察组和对照组间DMII、MDA、NOX2、NOX4及DUOX1蛋白水平差异无统计学意义(P>0.05).结论 五水头孢唑林钠联合热淋清颗粒对肾结石术后泌尿系统感染的疗效优于五水头孢唑林钠单用的效果,值得在临床上推广应用.