不孕不育症患者外周血和子宫内膜AsAb、EmAb、AcAb、AoAb、ToxAb的检测价值研究

摘要

目的 检测女性不孕不育患者血清和子宫内膜AsAb、EmAb、AcAb、AoAb、ToxAb,为女性不孕不育症患者提供临床诊断和治疗依据.方法 临床筛选60例女性不孕不育症患者,运用金标检测和ELISA检测试剂盒进行血清和子宫内膜免疫五项检测并进行统计分析.结果 不孕不育患者免疫五项检出率明显高于对照组且在血清和子宫内膜中五项指标的浓度均有不同程度的升高.在原发性不孕患者中AsAb阳性多见;在继发性不孕患者体中EmAb阳性多见;在反复流产不育患者甲AcAb和ToxAb阳性多见.结论 免疫因素为女性不孕不育的主要因素,在临床诊断和治疗中具有重要的意义.%Objective To detect the levels of anti-sperm antibody (AsAb),endomentrial antibody (EmAb),anti-ovarian antibody (AoAb),anti-cardiophospholipid antibody (AcAb) and toxoplasmosis antibody (ToxAb) in serum and endometrium of women patients with infertility in order to provide basis for clinical diagnosis and treatment of female infertility.Methods Sixty patients with female infertility were enrolled in the study.The five immune indexes of serum and endometrium including AsAb,EmAb,AcAb,AoAb and ToxAb were detected by gold standard detection and ELISA kit,then the detection results were statistically analyzed.Results The detection rates of the five indexes in patients with female infertility were significantly higher than those in control group,moreover,the levels of the five indexes in serum and endometrium of patients were increased at different extent.The positive AsAb was more common in patients with primary infertility,and positive EmAb was more common in patients with secondary infertility,furthermore,positive AcAb and positive ToxAb were more common in patients with recurrent spontaneous abortion.Conclusion Immune factors are the main factors of female infertility,therefor,which are of great significance in clinical diagnosis and treatment.