缬沙坦与硝苯地平对高血压病患者蛋白尿及肾功能的影响

摘要

目的观察比较缬沙坦与硝苯地平对于高血压患者白蛋白尿及肾功能的疗效。方法38例高血压病患者随机分为缬沙坦治疗组和硝苯地平治疗组，疗程12周，观察治疗前后血压及肾功能指标的变化。结果两药均可以降低患者动脉压(均P＜0.01)，且两组间比较无显著性差异(P＞0.05)，但缬沙坦治疗组白蛋白尿显著减少(P＜0.01)，而硝苯地平治疗组治疗前后比较白蛋白尿无明显变化(P＞0.05)。结论缬沙坦改善蛋白质作用不依赖于动脉血压的降低，其机制可能与改善肾脏血流量或肾小球通透性有关。%Objective To study the effects of valsartan and nifedipine on proteinuria and renal function of patients with hypertension. Methods 38 cases with hypertension were randomly divided into valsartan group (treated with valsartan) and nifedipine group (treated with nifedipine),each was treated with valsartan or nifedipine for 12 conseacutive weeks,blood pressure and renal function were measured before and after the treatment.Results Comparison to the treatment begore the arterial pressures were significantly decreased in both groups after the treatment,but there were no differences between two groups.Urinary albumin excretion was significantly reduced in valsartan group after the treatment,whereas no significant changes occured in nifedipine group.Conclusions The effects of valsartan on proteinuria were relationship to modification of arterial circulalion or improvement of glomerular permeabiliry.