巴戟天多糖对去卵巢大鼠骨质疏松症的防治作用

摘要

Objective To observe the protective and therapeutic effects of morindae officinails polysaccha-rides on osteoporosis of ovariectomized rats. Methods Thirty adult female SD rats were divided randomly into sham-operated group, model group, morindae officinails polysaccharides group. Every group had ten rats. We extract-ed bilateral ovaries to establish osteoporosis model, which were treated with medicine two weeks postoperationally for consecutively 3 months. Then we observed the protective and therapeutic effects of morindae officinails polysaccha-rides on rat bone mineral density (BMD), bone mineral content, estrogen, osteocalcin, 1, 25-dihydroxyvitamin D3. Results After 3 months, the morindae officinails polysaccharides group could significantly improve the BMD, bone mineral content, osteocalcin, 1, 25-dihydroxyvitamin D3 of the ovariectomized rats, compared with model group. Conclusion Morindae officinails polysaccharides can antagonize osteoporosis of the ovariectomized rats.%目的：观察巴戟天多糖对去卵巢大鼠骨质疏松症的影响。方法成年雌性SD大鼠30只，随机分为假手术组、模型组、巴戟天多糖组，每组10只。采用摘取双侧卵巢法建立骨质疏松模型，造模2周后开始给药，给药3个月后观察巴戟多糖天对大鼠骨密度、骨矿物质含量、血清雌二醇、骨钙素及1，25-二羟基维生素D3的影响。结果给药3个月后，与模型组比较，巴戟天多糖组能显著提高去卵巢大鼠的骨密度、骨矿物质、1，25-二羟基维生素D及骨钙素的含量。结论巴戟天多糖对去卵巢所致的大鼠骨质疏松症具有良好的防治作用。