Objective To investigate the application of Fuzhiqing ointment in the treatment of moderate to severe acne vulgaris. Methods 400 patients with moderate to severe acne vulgaris were randomly divided (100 cases each) into topical group (Fuzhiqing ointment for topical use), routine group (routine oral drugs), combination group (Fuzhiqing ointment and routine oral drugs) and mask group (routine oral drugs and Fuzhiqing ointment used for fa-cial mask). Efficacy and adverse reactions were observed for 4 weeks. Results There was no statistical difference of effective rate between topical group and routine group. The effective rate of combination group was higher than that of topical group. The effective rate of mask group was 87%, which was higher than those of other groups and all the dif-ferences were statistical significant. 4 patients felt mild epigastric discomfort and 1 patient in mask group had mild fa-cial flushing and burning. All these adverse reactions needed no treatment. Conclusion For treating patients with moderate to severe acne vulgaris, Fuzhiqing ointment has the advantages of good efficacy and high safety. It was bet-ter when performed with facial mask combined with routine treatment. It was worthy of clinical popular application.%目的：探讨肤痔清软膏对中重度寻常痤疮的临床治疗作用。方法400例中重度寻常痤疮患者随机分为外用组(只外涂肤痔清软膏)、常规组(常规口服药物治疗)、联合组(常规口服药物联合外涂肤痔清软膏)和倒膜组（常规口服药物联合外涂肤痔清软膏和面部倒膜治疗）各100例，给予相应治疗4周，观察疗效和不良反应。结果外用组与常规组的有效率差异无统计学意义(P＞0.05)，联合组的有效率优于外用组，倒膜组的有效率为87.00%，优于其余各组，其差异均有统计学意义(P＜0.05)。有4例患者出现轻微上腹部不适，倒膜组有1例患者出现面部轻微潮红和烧灼感，均无需处理。结论肤痔清软膏治疗中重度寻常痤疮，疗效好，安全性高，尤以用作面部倒膜并联合常规治疗的综合疗法效果更为显著，值得临床推广应用。
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