血管内皮生长因子研究进展及其与胰腺癌的相关研究

摘要

In the growth and metastasis process of pancreatic carcinoma, angiogenesis is a vital step which makes the tumor have the ability of metastasis from a small nodule. Vascular endothelial growth factor (VEGF) is viewed as a cru-cial driving factor and the major regulator in the process of angiogenesis. With the deepening research of the mechanism of VEGF pathway, studies on VEGF and pancreatic cancer have become a focusing topic. Therefore, the relationship between VEGF and pancreatic carcinoma is reviewed in this article. Then, we summarized the recent findings from the following as-pects:the characteristics of VEGF (including the structure and function, modulating factors and regulation mechanism), the clinical significance of VEGF and anti-VEGF therapy in pancreatic carcinoma.%在胰腺癌的生长和转移中新生血管形成（Angiogenesis）是其从小结节进展成为具有侵袭能力重要的一步。血管内皮生长因子是肿瘤血管新生过程中最重要的驱动因子，血管新生的主要调节者。随着VEGF途径作用机制研究的日益深入，VEGF与胰腺癌的关系也受到越来越多的关注。本文从VEGF的结构和功能、调控因素及相关调控机制，VEGF在胰腺癌中表达的临床意义，以及抗VEGF治疗在胰腺癌中的相关研究进展方面，对VEGF在胰腺癌中的研究现状做一介绍。