维生素D与2型糖尿病患者颈动脉粥样硬化关系的研究进展

摘要

Diabetes of long duration can cause chronic complications of blood vessels, heart, kidneys, nervous system and other tissues. Vitamin D is a classic regulator of calcium and phosphorus, which has a variety of biological ef-fects, including protecting pancreatic B cells, relieving inflammation, reducing arterial endothelial injury. In recent years, an increasing number of clinical and animal model experiments show that Vitamin D is a new risk factor for cardiovascu-lar disease in patients with type 2 diabetes mellitus, but researches published still exist differences for this point. This arti-cle reviews the current related researches and studies.%长期的糖尿病病程可引起血管、心脏、肾脏、神经系统等组织的慢性并发症.维生素D是经典的钙磷调节剂,具有多种生物学效应,包括对胰岛B细胞的保护作用、缓解炎性反应、减少动脉内皮损伤等.近年来愈来愈多的临床及动物模型试验表明,维生素D是2型糖尿病心血管疾病的一个新的危险因素,目前已发表文献对此仍存有分歧,本文就此相关机制及临床研究做一综述.