目的 探讨维生素D辅助治疗老年人社区获得性肺炎(CAP)的临床疗效.方法 选择东莞市常平医院呼吸科于2016年12月至2017年3月间收治的100例老年CAP患者为研究对象,根据随机数表法将患者分为观察组和对照组,每组50例,对照组患者予常规抗感染等治疗,观察组联合应用骨化三醇治疗,疗程为4周.比较两组患者治疗前后的血清25-羟维生素D[25-(OH)D]、超敏C反应蛋白(hs-CRP)水平及临床疗效.结果 治疗后,观察组患者的血清25-(OH)D水平为(34.22±14.63)ng/mL,明显高于对照组的(28.36±15.17)ng/mL;血清hs-CRP水平为(9.15±4.43)mg/L,明显低于对照组的(13.28±5.42)mg/L,差异均有统计学意义(P<0.05);观察组患者的治疗总有效率为95.24％,明显高于对照组的85.71％,差异有统计学意义(P<0.05).结论 维生素D辅助治疗老年CAP可提高体内维生素D水平,降低炎症反应程度,提高临床疗效.%Objective To investigate the clinical efficacy of vitamin D in the treatment of elderly patients with community acquired pneumonia (CAP). Methods A total of 100 elderly patients with CAP treated in Respiratory De-partment, Dongguan Changping Hospital from December 2016 to March 2017 were selected and divided into observa-tion group and control group according to the random number table, with 50 cases in each group. The control group was treated with routine anti-infection treatment, and the observation group was treated with calcitriol, both for 4 weeks. The changes of serum 25-(OH)D and hypersensitive C-reactive protein (hs-CRP) levels were compared be-tween the two groups before and after treatment, as well as the clinical efficacy. Results After treatment, the serum 25-(OH)D level was (34.22±14.63) ng/mL, significantly higher than (28.36±15.17) ng/mL in the control group (P<0.05); the serum hs-CRP was (9.15±4.43) mg/L, significantly lower than (13.28±5.42) mg/L in the control group (P<0.05); the total efficiency of the observation group was 95.24％, significantly higher than 85.71％ in the control group (P<0.05). Conclusion Adjuvant treatment with vitamin D can improve the vitamin D level in elderly CAP patients, re-duce the inflammatory reaction and improve the clinical efficacy.
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