川楝子正丁醇部位对小白鼠的急性毒性

摘要

为探明川楝子正丁醇部位的急性毒性，通过预试验测定出川楝子正丁醇部位的最小全死量（Dm）和最大全不死量（Dn），然后进行川楝子正丁醇部位对小白鼠的急性毒性试验。结果表明：川楝子乙醇提取物的正丁醇部位对小白鼠单次口服的半数致死量（LD50）为2．7571 g／kg，95％可信限为2．7419～2．7723 g／kg。死亡小白鼠急性毒性主要表现为安静少动、腹卧昏睡、呼吸急促、连续抽搐。川楝子正丁醇部位毒性较低，符合低毒化合物标准（500～5000 mg／kg）。%To evaluate the acute toxicity of the n-butanol fraction from M.toosendan,minimum amount of Dm and the maximum amount of Dn of the n-butanol fraction from M.toosendan was measured by preliminary test.Then design a test to evaluate the acute toxicity for mice.The results showed that the LD50 of n-butanol fraction from M.toosendan on single dose in mice was 2.757 1 g/kg,95% confidence-limit was 2.741 9 ~ 2.772 3 g/kg.The main acute toxicity symptoms and signs of dead mice included negligent action,shortness of breath,continuous convulsions.According to the national standard of acute toxicity test,the n-butanol fraction from M.toosendan belonged to low-toxic compounds.