刺毛黧豆在痒觉研究中的应用—研究史、机制及方法学浅谈

摘要

Mucunain Prurien,Cowhage is a tropical legume, burr itching of their pod. Active ingredients for mucunain. This plant produces the itching sensation and itching caused by classic similarities and differences compared to the substance histamine exists. Present on this substance caused the itching sensation, nerve conduction, related receptor and characterization of the skin of some studies. At the same time, natural mucunain stimulate the skin causing itching sensation, and experiments began inactivation of black beans after adding other substances to epidermal behavioral studies, the progress made in the study of mucunain prurien has the potential to become itchy sleep research tool.%刺毛黧豆（MucunainPmden，Cowhage）是一种热带豆科植物，其豆荚毛刺有致瘁作用。有效成分为黧豆蛋白酶（mucunain）。这种植物产生的痒觉与经典致瘁物质组胺相比存在相似及区别。目前对这种物质引起的痒觉，在神经传导，相关受体及皮肤行为学性质等方面有一些研究。同时，天然黧豆毛刺刺激皮肤引起痒觉，而一些实验开始采用灭活黧豆毛刺添加其他物质后进行表皮行为学研究，这些研究的进展使得黧豆毛刺具有成为瘁觉研究实验工具的潜力。