Objective To investigate the enalapril hydrochlorothiazide clinical efficacy of treatment of essential hypertension. Methods Dec. 2008 to Dec. 2010 our hospital 62 patients with essential hypertension were randomly divided into treatment group and control group 2 weeks before treatment to stop taking other antihypertensive drugs, and to monitor blood pressure. Control group was given enalapril 10 mg/time, 2 times a day;the treatment group were given on the basis of hydrochlorothiazide l2.5mg/time, 1 day, and even clothes 8 weeks of therapy were compared. Results After treatment, the treatment group were efifciency and total efifciency as compared with the control group, there were signiifcant differences (P<0.05). Treatment and control groups in systolic blood pressure, diastolic blood pressure than those before treatment was signiifcantly decreased in the treatment group reduced blood pressure more signiifcantly than the control group (P<0.05). The incidence of adverse reactions compared the two groups signiifcantly different (P<0.05). Conclusion Enalapril hydrochlorothiazide antihypertensive treatment of essential hypertension have synergistic effects, better than drugs, while two drugs may offset some of the adverse reactions, safety, and worth promoting.% 目的探讨依那普利联合氢氯噻嗪治疗原发性高血压的临床疗效。方法将2008年12月至2010年12月我院住院原发性高血压患者62例随机分为治疗组和对照组，两组治疗前2周停服其他降压药物，并监测血压。对照组给予依那普利10mg/次，每日2次；治疗组在对照组基础上给予氢氯噻嗪l2.5mg/次，每日1次，连服8周，观察比较两组的治疗疗效。结果疗程结束后，治疗组显效率和总有效率与对照组相比，均有显著性差异（P＜0.05）。治疗组和对照组的收缩压、舒张压均较治疗前明显降低，且治疗组血压降低较对照组更明显（P＜0.05）。两组不良反应发生率比较差异显著（P＜0.05）。结论依那普利联合氢氯噻嗪治疗原发性高血压具有协同降压作用，优于单纯用药，同时两种药物的某些不良反应可相互抵消，安全性好，值得推广。
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