血浆同型半胱氨酸与动脉粥样硬化及脑梗死的相关性研究

摘要

目的探讨血浆同型半胱氨酸水平与动脉粥样硬化性脑梗死的关系。方法选83例动脉粥样硬化性脑梗死患者为脑梗死组，同期选择健康体检者57例为对照组，检测所有研究对象血浆同型半胱氨酸（HCY），应用颈动脉多普勒彩色超声检查颈动脉内膜-中层厚度（IMT）。结果脑梗死组患者血浆 HCY，IMT 均显著高于对照组，差异有统计学意义，且患者的血浆 Hcy 水平与 IMT 呈正相关。结论血浆同型半胱氨酸水平与颈动脉粥样硬化关系密切，是动脉粥样硬化性脑梗死的危险因素。%　　Objective To investigate the relationship of plasma homocysteine(HCY) between the atherosclerosis and cerebral infarction. Methods Eighty three patients with cerebral infarction were chosen for the cerebral infarction (CI) group and fifty-seven healthy people of examination for the control group. The levels of plasma HCY were measured, and measure the intimal-medial thickness (IMT) of internal carotid artery by carotid duplex ultrasonography scanning simultaneously. Results The levels of plasma HCY and IMT were significantly higher in the group of CI than those in control group (P<0.05). The level of plasma HCY was positively correlated with IMT(P<0.05). Conclusion There is a close correlation between high plasma HCY level and atherosclerosis, and the plasma HCY level is a risk factor of the cerebral infarction.