碘131与抗甲状腺药物治疗甲亢的近远期疗效观察

摘要

Objective Iodine 131 anti-thyroid drugs and treatment of hyperthyroidism near, forward curative effect. Methods Select 250 cases of thyroid function in patients with hyperthyroidism (hyperthyroidism) for A group, to their use of iodine 131 treatment, the other 250 cases of patients with hyperthyroidism for group B, the use of antithyroid drugs (ATD) treatment. Observation than two groups of drug treatment of near future curative effect. Results A group of patients with hyperthyroidism using iodine 131 after treatment, A 210 cases were cured and 35 cases were improved invalid in 5 patients;group B patients with hyperthyroidism using ATD after treatment, a 121 cases were cured, 75 cases of better. A group of patients after treatment in A heart and liver function damage and reduce blood picture (appear A and above) there were 12 cases, there were 66 cases of group B, two groups of comparisons with significant difference (P<0.01). Conclusion Although the iodine 131 patients after treatment of hyperthyroidism there a low incidence is higher, goggle-eyed improve were so poor phenomenon, in the clinical medicine, promote the use of this method.%　　目的观察碘131与抗甲状腺药物治疗甲亢近、远期疗效。方法选取250例甲状腺功能亢进症（甲亢）患者为 A 组，对他们使用碘131进行治疗，另选同期250例甲亢患者为 B 组，使用抗甲状腺药物（ATD）进行治疗。观察比对两组药物治疗的近、远期疗效。结果 A 组甲亢患者使用碘131治疗后，一次治愈210例，好转35例，无效5例；B 组甲亢患者使用 ATD 治疗后，一次治愈121例，好转75例。A 组治疗后患者出现甲心病以及肝功能受损和血象降低（出现1项及以上的）共发生12例，B 组共发生66例，两组比较差异具有显著性（P ＜0.01）。结论尽管采用碘131治疗甲亢后存在患者甲低发生率较高，突眼的改善较差等现象，在临床医学中推广使用这种方法。