胰岛素泵不同基础率输注治疗脆性糖尿病的疗效比较

摘要

Objective To discuss the clinical effect of 6 parts continuous subcutaneous insulin infusion (CSII) and 24 parts CSII on patients with fragile diabetes mellitus. Methods Thirty patients with fragile diabetes mellitus were randomly divided into 6 parts CSII group(15 patients) and 24 parts CSII group(15 patients). The levels of plasma glucose, insulin doses, therapeutic time and hypoglucemia were observsed.Result Two CSII groups all could lower blood sugar effectively(P<0.01), and there was no significant differences between two CSII groups(P>0.05).The therapeutic time, insulin doses and hypoglucemia of 24 parts CSII group was superior to 6 parts CSII group(P<0.01, P<0.01, P<0.01). Conclusion The limited evidence shows that 24 parts CSII group is superior to 6 parts CSII group in treating patients with fragile diabetes mellitus%　　目的比较6段法与24段法两种胰岛素泵基础率输注方式治疗脆性糖尿病的临床疗效及安全性。方法选择20例脆性糖尿病患者，随机分为两组，A组设置6时段基础率，B组设置24时段基础率。两组患者均测血糖谱（每天三餐前、三餐后2h、睡前及凌晨3点血糖）。根据血糖结果调整胰岛素用量，直至血糖达标。观察血糖达标时间、每天胰岛素用量及低血糖发生率。结果两组患者治疗后血糖值均能明显下降，差别有统计学意义(P<0.01)；两组间治疗前后比较,差别无统计学意义(P>0.05)。24时段基础率治疗后血糖达标所用时间短，胰岛素用量少，低血糖发生率低，两组差别有统计学意义(P<0.01)。结论24段法胰岛素泵基础率输注模式治疗脆性糖尿病的临床疗效及安全性优于6时段基础率输注。