Objective To investigate the drug resistance of ureaplasma urealyticum to tetracyclines, quinolones and macrolides. Methods Select 75 cases of urogenital infections with ureaplasma urealyticum infection positive, take ureaplasma urealyticum incubation experiment and susceptibility test, observe the in vitro growth and drug resistance of to antibiotics of ureaplasma urealyticum. Results Total 1020 susceptibility tests of 75 cases, 430 of resistance, 42.1%, 590 of moderately sensitive and sensitive, 57.8%, 65 cases got drug resistance to two or more types, 86.7%. From high to low, the resistance rates of 10 kinds of antibiotics to be tested were ciprolfoxacin, olfoxacin, roxithromycin, azithromycin, sparlfoxacin,spctinomycin, doxycycline, minocycline, clarithromycin, josamycin. Conclusion Ureaplasma urealyticum got a higher incidence of drug resistance, and multi-drug resistance phenomenon was widespread, clinical treatment should according to patient's drug sensitivity.%目的：探讨解脲支原体对四环素类、喹诺酮类及大环内酯类药物的耐药情况。方法选择于2011年10月至2012年10月在我站治疗的解脲支原体阳性的泌尿生殖器感染患者75例，进行解脲支原体培养和药敏试验，观察解脲支原体的体外生长情况及其对抗生素的耐药情况。结果75例患者共进行1020孔药敏试验，其中耐药430孔，占42.1%，中敏及敏感590孔，57.8%，同一患者对2种以上药物耐药的有65例，占86.7%。10种被测试的抗生素的耐药率由高到低依次为环丙沙星、氧氟沙星、罗红霉素、阿奇霉素、司帕沙星、大观霉素、美满霉素、强力霉素、克拉霉素、交沙霉素。结论解脲支原体耐药发生率较高，且普遍存在多重耐药现象，临床用药应根据患者药敏情况来选择药物。
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