创伤严重脓毒血症和MODS免疫调理治疗的临床研究

摘要

Objective Discuss on clinical effects of Immune conditioning treatment of patients with trauma, severe sepsis and MODS.Methods Selected 74 patients with trauma, severe sepsis and MODS in our hospital from April 2012 to April 2014. Randomly divided into experimental group and control group(n=37). The patients in the control group only received the conventional treatment, the experimental group increased immune conditioning treatment on the basis.Results After treatment, the APACHEⅡ score, IL-6, TNF-α, CD14+ monocyte HLA-DR expression levels and survival rates signiifcant differences comparison of the two groups, had Statistical signiifcance (P<0.05).Conclusion Immune conditioning treatment of patients with trauma, severe sepsis and MODS can signiifcantly improve immune function, improve the therapeutic effect to ensure good prognosis effects.%目的：探讨针对创伤、严重脓毒症和多器官功能障碍综合征（MODS）患者开展免疫调理治疗的临床效果。方法选取本院2012年4月至2014年4月收治的创伤、严重脓毒症和MODS患者74例，采用随机数字法分为实验组与对照组各37例，对照组病例仅行ICU内常规治疗，实验组在其基础上增加免疫调理治疗方法。结果治疗后，两组患者的APACHEⅡ评分、IL-6、TNF-α、CD14+单核细胞HLA-DR表达水平以及存活率比较存在显著差异，具有统计学意义（P＜0.05）。结论针对创伤、严重脓毒血症和MODS患者采用免疫调理治疗可显著改善其机体免疫状况，提高治疗效果保证良好预后效果。