目的：探讨姑息放疗治疗双肺多发转移癌的价值。方法1999年3月至2007年5月我院肿瘤科收治38例双肺多发肺转移癌患者，均给予姑息放疗。现对这些患者的临床资料进行总结分析。结果本组放疗结束时转移瘤CR率为15.8%（6/38），PR率为50.0%（19/38），有效率（PR+CR）达65.8%。原发肿瘤为鼻咽癌、乳腺癌、肝癌、结直肠癌的中位生存期分别为13.5、22.0、6、8.5个月。1~2级放射性肺炎发生率为26.3%（10/38）；3级为15.8%（6/38）；4~5级为0。结论恶性肿瘤肺多发转移可以采用全肺放疗+局部小野补量治疗，尤其适用于原发肿瘤对放疗中高度敏感、化疗有效的患者，可获得较好疗效。不良反应可耐受。%Objective To investigate the whole-lung irradiation value on the pulmonary metastases. Methods From March 1999 to May 2003, there were 24 patients with multiple double-pulmonary metastases accepted whole-lung irradiation in the department of oncology, Jiangmen center hospital. Data of the 24 patients were retrospectively analyzed. Results After radiotherapy, the complete response rate of lung transferring tumor was 15.8%(6/38), partial response rate was 50.0%(19/38)and the overall response rate(PR+CR)was 65.8%. As the primary tumor was nasopharyngeal carcinoma, breast cancer, liver cancer, colonic and rectal cancer, the median survival time was 13.5, 22.0, 10.5, 8.5 months, respectively. Grade 1-2 radiation pneumonitis were 26.3%(10/38), grade 3 were 15.8%(6/38), grade 4-5 were 0. Conclusion Whole-lung irradiation plus local boost is able to treat pulmonary metastases of malignant tumor. It’s applicable especially to the patient whose primary tumor is sensitive to radiotherapy and no response to chemotherapy. The curative effect is satisfaction and the side effects are acceptable.
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