实现赖氨匹林工业化生产的工艺研究

摘要

赖氨匹林是一种阿司匹林和DL-赖氨酸的复盐，为了满足工业化生产，节约成本，直接在市面上购买阿司匹林和DL-赖氨酸合成赖氨匹林，通过此合成方法对反应中的析晶温度、析晶时间、滴加温度、反应物浓度、反应物之间配比进行较全面的考察，从而选定了最为经济、高产率、高质量且适合于工业化生产的工艺条件和步骤。%Aspirin-DL-lysine was a kind of aspirin and DL-lysine complex salt. In order to meet the needs of industrial production and cost savings, buying aspirin and DL-lysine in the market directly, aspirin-DL-lysine was synthesized. Through the investigation of the crystallization temperature of reaction, the crystallization time, dropping the temperature, the concentration of reactants, the ratio between reactants conduct A comprehensive of the synthesis method, the most economical, high yield, high quality, and conditions and steps suitable for industrialized production was selected.