微波促进的手性双苯并咪唑基化合物的合成

摘要

微波加热能提高反应速率,同时由于微波产生的微波等离子体中常可存在高能态原子、分子和离子,因而可使一些热力学上认为不可能发生的化学反应得以发生。本文以邻苯二胺、谷氨酸、天冬氨酸为原料,多聚磷酸( PPA)为催化剂,采用微波促进合成了2种手性双苯并咪唑基化合物：(1S),3-二(2-苯并咪唑)-1-丙胺(bbImpa)、(1S),2-二(2-苯并咪唑)乙胺( bbImea),优化了反应条件。在较短时间内产率即可以分别达到80%和76%,与常规方法相比,反应速度提高了近30倍。%Microwave heating can increase the reaction rate, at the same time, the microwave produced by microwave plasma often exist high-energy atoms, molecules and ions, thus the thermodynamics of some that may not occur chemical reaction can occur. Under the microwave irradiation, the bis (2-benzimidzazoly) compounds bbImpa and bbImea were synthesized respectively by condensation of o-phenylenediamine and L (+)-Glutamic acid, L (+)-Aspartic acid, and were catalyzed by PPA. The reaction time was decreased to only several decades minute, the yield was 80% and 76%, respectively. Compared with the conventional synthesis, the rate of reaction was up to 30 times faster respectively under such condition.