3-羧基-5-氟苯基硼酸是一种重要的有机合成中间体，可通过suzuki 芳基偶联反应合成多烯烃、苯乙烯和联苯的衍生物，从而应用于众多天然产物、有机材料的合成中。本文以5-氟-3-溴甲苯为原料，利用两步反应合成目标产物的合成工艺：①利用有机锂试剂法合成3-氟-5-甲基苯硼酸；②将3-氟-5-甲基苯硼酸经过氧化反应合成目标产物，总产率为75.5%。本合成路线操作简单，原料的价格低，符合工业化生产的要求，可以进行工业化生产。%3-borono-5-fluorobenzoic acid is an important intermediate for organic synthesis, widely used in organic synthesis, by suzuki aryl-coupling reaction synthesis of olefins, styrene and biphenyl derivative, which is applied to the synthesis of many natural products, organic materials. The use of a two-step reaction synthesis of the target product synthesis process was described using organic lithium reagent synthesis of (3-fluoro-5-methylphenyl) boronic acid. The target product was synthesized using (3-fluoro-5-methylphenyl) boronic acid through the oxidation reaction, the total yield was 75. 5%. This synthetic route is simple with low price of raw material, and accord with the requirement of industrial production to industrial production.
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