N,N-二甲基-3-氯丙胺盐酸盐的相转移催化合成

摘要

PEG 600 was used as phase-transfer catalyst to synthesize N, N-dimethyl-3-chloropropylamine Hydrochloride from dimethyl amine and 1-bromo-3-chloropropane. The effects of factors, such as the concentration of the catalyst of PEG 600, the mole ratio of dimethyl amine to 1-bromo-3-chloropropane, the reaction temperature and the reaction time on the yield, were examined. The optimal reaction conditions were determined as follows:the mole ratio of dimethyl amine to 1-bromo-3-chloropropane was 1. 2, PEG 600 catalyst was 2. 0 g, the reaction time was 4 h, the reaction temperature was 35~40 ℃, and the yield reached 73. 7%.%以1,3-溴氯丙烷和33%二甲胺水溶液为原料, PEG-600为相转移催化剂进行烷基化反应得到了N,N-二甲基-3-氯丙胺盐酸盐,考察了相转移催化剂用量、二甲胺水溶液与1,3-溴氯丙烷摩尔比、反应温度和反应时间等因素对产率的影响。确定适宜反应条件为： n(二甲胺水溶液)n(1,3-溴氯丙烷)=1.2, PEG-6002.0 g,反应时间4 h,反应温度为35~40℃,产率可达73.7%。