2-（3-溴苯）二氢噻唑化合物的合成

摘要

The biosynthesis of thiazolines seemed to involve the enzymatic oxidation of thiazolidine intermediates, formed from the coupling reaction of cysteine or cysteamine with aldehydes, issues from the strecker degradation of amino acids. The factors of reaction temperature, solvents, molar ratio and base, found a green, simple and efficient synthesis of thiazoline were explored, used the cysteamine and 3-Bromobenzonitrile as materials, the DBH as reaction catalyst, the dichloromethane as solvent to compound thiazoline in normal temperature. This method has the characteristics of wide applicability, high yield, simple and convenient, mild reaction conditions and environment friendly.%二氢噻唑化合物的合成通常采用四氢噻唑中间体的酶促氧化、半胱氨酸与醛的偶联反应、从氨基酸的斯特雷克降解等方法。通过对反应温度、溶剂和碱等因素的探究，找到了一种绿色、简便、高效合成二氢噻唑类化合物的路径。即以半胱胺盐酸盐与间溴苯腈为原料， DBH为反应催化剂，二氯甲烷为溶剂，常温下合成的方法。该方法具有适用性广、收率高、后处理简便、反应条件温和、环境友好等特点。