7-BROMO-1,2-METHYLENE-5- (2-HALOGENPHENYL) -1H-2,3-DIHYDRO-1,4-BENZODIAZEPINES AND PROCEDURE FOR THE PREPARATION OF 7-BROM-5- (2-HALOGENPHENYL) -1H- 2,3-DIHYDRO-1,4-BENZODIAZEPINE COMPOUNDS OR ACID ADDITION SALTS THEREOF

摘要

Disclosed are 7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines of the formula I IMAGE I in which R1 is a hydrogen atom or a lower alkoxy or alkanoyloxy radical and R2 is a halogen atom. The compounds possess psychopharmacological, and especially anti-aggressive properties. To manufacture compounds of formula I, corresponding 2-halomethyl-7-bromo-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines are cyclized to corresponding 7-bromo-1,2-methylene-5-(2-halophenyl)-1H-2,3-dihydro-1,4-benzodiazepines and in these the aziridine ring is opened through treatment with a lower alcohol or a lower carboxylic acid in the presence of a Lewis acid.