肝脏实时组织弹性成像评分与肝纤维化四项指标相关性的探讨

摘要

目的 探讨实时组织弹性成像(RTE)评分与血清肝纤维化四项指标评价慢性乙型肝炎、乙肝肝硬化患者肝纤维化程度的相关性.方法 选择慢性乙型肝炎、乙型肝炎肝硬化患者62例,均常规超声扫查后行RTE检查,图像根据弹性程度分为0～4分,将RTE评分与纤维化指标[Ⅲ型前胶原氨基末端肽(PⅢNP)、透明质酸(HA)、Ⅳ型胶原(CIV)、层粘连蛋白(LN)]进行对比分析.结果 RTE评分随纤维化指标水平的升高而增加,不同评分组各指标水平比较差异有统计学意义(P＜0.05).RTE评分与纤维化指标水平呈正相关(P＜0.01).结论 RTE技术为诊断肝纤维化提供了新手段,有望成为客观评价肝纤维化程度的无创检查方法.%Objective To investigate the correlation between real-time tissue elastography( RTE ) and four indexes of serum liver fibrosis in patients with chronic hepatitis B or hepatitis B cirrhosis. Methods Sixty-two patients with chronic hepatitis B or hepatitis B cirrhosis were enrolled in the study, and they all received routine ultrasound and RTE examination. The elasticity scores ranged from 0 to 4. A comparative analysis was done between elasticity scores and the indexes of serum liver fibrosis including procollagen Ⅲ N-terminal peptide( P Ⅲ NP ), hyaluronic acid( HA ), collagen type Ⅳ ( CIV ) and laminin( LN ). Results The elasticity scores increased when the levels of serum liver fibrosis indexes increased. There were significant differences in levels of the four indexes among different-score groups ( P < 0. 05 ). The elasticity scores correlated positively with the levels of serum liver fibrosis indexes ( P < 0. 01 ). Conclusion RTE provides a new method for the diagnosis of liver fibrosis, and is expected to become a non-invasive and objective examination method in evaluating the level of liver fibrosis.