存活素、细胞 S相激酶相关蛋白2在非小细胞肺癌中的表达及其意义

摘要

Objective To investigate the expression and significance of Survivin and S -phase kinase-associated protein-2( Skp2) in non-small cell lung cancer .Methods The specimens were collected from 60 cases of non-small cell lung cancer tissues and 40 cases of adjacent normal lung tissues ,immunohistochemistry was used to test the expressions of Survivin and Skp 2 in the specimens , and the relationship of the expressions with clinical pathology was analyzed . Results The expression rates of Survivin ,Skp2 in non-small cell lung cancer tissues were higher than those in adjacent normal lung tissues ( P<0 .05 ) .The positive rate of Skp 2 in patients with lung cancer correlated with lung cancer pathological type,differentiation degree,TNM staging,lymph node metastasis,smoking and Survivin expression(P<0.05). There was a positive correlation between Survivin expression and Skp 2 expression in non-small cell lung cancer ( P<0.05) . Conclusion Overexpressions of Survivin ,Skp2 may be involved in the occurrence and development of non-small cell lung cancer,the detection of the expressions of Survivin and Skp2 in lung cancer tissues can benefit the diagnosis and prognosis of lung cancer patients .%目的：探讨存活素（ Survivin ）基因和细胞S相激酶相关蛋白2（ Skp2）在非小细胞肺癌组织中的表达及其意义。方法收集60例非小细胞肺癌患者的肺癌组织标本和40例癌旁正常肺组织标本，采用免疫组化技术检测标本中Survivin和Skp2的表达，并分析其与患者的临床病理之间的关系。结果 Survivin、Skp2在非小细胞肺癌组织中的表达率高于癌旁正常肺组织（ P＜0．05）。肺癌患者Skp2阳性率与肺癌组织学病理类型、分化程度高低、TNM分期、是否伴随淋巴结转移、吸烟与否及Survivin表达有关（ P＜0．05）。非小细胞肺癌组织Survivin与Skp2的表达呈正相关关系（ P＜0．05）。结论 Survivin、Skp2过度表达可能参与非小细胞肺癌的发生发展，检测肺癌组织Survivin与Skp2的表达有助于临床诊治肺癌患者和判断预后。